Library / Kisspeptin-10
Some human studies
Kisspeptin-10
Neuropeptide (reproductive hormone signal) · Hormones & fertility
What it is
A natural brain signal that sits at the top of the reproductive hormone chain. It triggers the release of GnRH, which then raises LH and FSH.
What research covers
Human studies show kisspeptin raises LH and testosterone in men, and it has been tested as a gentler trigger for egg release in IVF. It is still a research medicine.
Reported side effects
- Generally well tolerated in studies
- Injection-site reactions
Not suitable for, or talk to a doctor first
- Hormone-sensitive cancers
- Pregnancy
Good to know
- Continuous exposure can switch the hormone signal off instead of on.
Legal status
| Australia | Not an approved medicine in Australia. Peptides like this are generally prescription-only (Schedule 4) and need a prescription to import. Check current rules with the TGA. |
|---|---|
| United States | Investigational. Not FDA-approved. |
| Sport | Prohibited by the World Anti-Doping Agency (WADA) at all times. |
Rules change. Check with the TGA (Australia), your local regulator, or WADA for sport.
Key references
- Dhillo et al. Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males. J Clin Endocrinol Metab, 2005.
- Abbara et al. Kisspeptin as a trigger of oocyte maturation in IVF. J Clin Invest, 2014.
General information, not advice. Talk to a qualified healthcare professional before starting, changing or stopping anything.