Library / KPV
Mostly lab & animal studies
KPV
Tripeptide from alpha-MSH · Immune & gut · Lys-Pro-Val
What it is
A three-amino-acid fragment of alpha-MSH, a natural hormone, that keeps its anti-inflammatory activity without its tanning effects.
What research covers
Studied mainly in mice and cell models of inflammatory bowel disease and skin inflammation. There are no published controlled human trials.
Reported side effects
- Little human safety data
- Mild stomach discomfort reported anecdotally
Not suitable for, or talk to a doctor first
- Pregnancy
- Conditions treated with immune-suppressing medicines, without medical advice
Legal status
| Australia | Not an approved medicine in Australia. Peptides like this are generally prescription-only (Schedule 4) and need a prescription to import. Check current rules with the TGA. |
|---|---|
| United States | Not FDA-approved. |
| Sport | Athletes should check the current WADA prohibited list, which changes every year. |
Rules change. Check with the TGA (Australia), your local regulator, or WADA for sport.
Key references
- Kannengiesser et al. Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease. Inflamm Bowel Dis, 2008.
- Dalmasso et al. PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation. Gastroenterology, 2008.
General information, not advice. Talk to a qualified healthcare professional before starting, changing or stopping anything.