Library / Semax
Some human studies
Semax
Synthetic fragment of ACTH (4-10) · Mind & sleep
What it is
A lab-made fragment of a stress hormone (ACTH) that has no hormone effects of its own. It is studied for focus, memory and protecting the brain.
What research covers
Registered in Russia since the 1990s, including for stroke recovery. Animal studies show it raises BDNF, a brain growth factor. Western trials are lacking.
Reported side effects
- Nasal irritation
- Feeling stimulated, anxious or irritable at higher amounts
Not suitable for, or talk to a doctor first
- Anxiety disorders
- Seizure disorders
- Pregnancy
Legal status
| Australia | Not an approved medicine in Australia. Peptides like this are generally prescription-only (Schedule 4) and need a prescription to import. Check current rules with the TGA. |
|---|---|
| United States | Not FDA-approved. |
| Sport | Athletes should check the current WADA prohibited list, which changes every year. |
Rules change. Check with the TGA (Australia), your local regulator, or WADA for sport.
Key references
- Dolotov et al. Semax, an analogue of adrenocorticotropin (4-10), binds specifically and increases levels of brain-derived neurotrophic factor protein in rat basal forebrain. J Neurochem, 2006.
General information, not advice. Talk to a qualified healthcare professional before starting, changing or stopping anything.